Artificial intelligence for accelerating time integrations in multiscale modeling

•AI-guided data-driven adaptive time stepping for accelerating multiscale modeling of demanding biophysical systems.•AI-ATS encapsulates physics-informed feature extraction and fully connected neural networks for inferencing optimal time-stepping.•An integrated workflow of multiscale simulator with AI-ATM facilitates seamless data flows and the AI inference on-the-fly.•We reduced 40% calculations while keeping 97% accuracy for modeling a flowing platelet with the standard methods.