Globotriaosylceramide-related biomarkers of fabry disease identified in plasma by high-performance thin-layer chromatography - densitometry- mass spectrometry

Carmen Jarne,Luis Membrado,María Savirón,Jesús Vela,Jesús Orduna,Rosa Garriga,Javier Galbán,Vicente L. Cebolla

Journal of Chromatography A（2021）

引用 6|浏览5

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摘要

•Identification of 19 Gb3 biomarkers in plasma extracts was performed by HPTLC-MS•HPTLC-UV densitometry was coupled to MS through an automated based interface•Saturated, methylated and unsaturated Gb3 species were identified by ESI and APCI-MS.•Saturated Gb3 species in Fabry's plasma were in higher concentration than in control.•Interface positioning precision provided information on Gb3 chromatographic widening.

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关键词

HPTLC,HPTLC-ESI-MS,HPTLC-APCI-MS,AMD,orcinol derivatization,Scanning densitometry,Sphingolipids,globotriaosylceramide,Fabry's disease

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