Relationship between tau, neuroinflammation and atrophy in Alzheimer's disease: The NIMROD study

Li Su,Ajenthan Surendranathan,Yujing. Huang,William R. Bevan-Jones,Luca Passamonti,Yong T. Hong,Robert Arnold,Patricia Vázquez Rodríguez,Yi Wang,Elijah Mak,Tim D. Fryer,Franklin I. Aigbirhio,James B. Rowe,John T. O'Brien

Information Fusion（2021）

引用 17|浏览29

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摘要

•AD is associated with significant regional increase of tau, microglia activation and GM atrophy.•Spatial distributions of different pathologies were highly overlapping.•GM atrophy mediated the effects of tau and neuroinflammation on cognitive impairments.•Multimodal imaging data fusion between multi-tracer PET and MRI.

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关键词

AD,MCI,Tau,Neuroinflammation,Mediation analysis,MRI,PET,Data fusion

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