Suppression of TGF-beta activity with remobilization attenuates immobilization-induced joint contracture in rats

•TGF-β1 and IL-1β activity is elevated after immobilization and remobilization.•TGF-β receptor I inhibitor LY2157299 increases ROM in immobilization-induced joint contracture.•Suppression of TGF-β activity with LY2157299 mitigates the progression of immobilization-induced joint contracture.