Fractionated regimen-suitable immunoradiotherapy sensitizer based on ultrasmall Fe4Se2W18 nanoclusters enable tumor-specific radiosensitization augment and antitumor immunity boost

The Sandwich-type polyoxotungstate nanoclusters could serve as the smart immunoradio-sensitizers with the help of immune checkpoint inhibitor to combat both local and metastasis tumors, mainly by augmenting the tumor-specific radiocatalysis and boosting the antitumor immunity for the abscopal effect. The small-sized nanosensitizers could also be metabolized rapidly out of the body, which is suitable for fractionated regimen of radiotherapy in clinic and thus beneficial for protection of the immune system.