Hypoxanthine phosphoribosyltransferase (HPRT)-deficiency is associated with impaired fertility in the female rat.

Stephen Meek,Linda Sutherland,Jun Wei,Roger Sturmey,Bert Binas,Michael Clinton,Tom Burdon

MOLECULAR REPRODUCTION AND DEVELOPMENT（2020）

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摘要

The purine hypoxanthine plays important role in regulating oocyte maturation and early embryonic development. The enzyme hypoxanthine phosphoribosyltransferase (HPRT) recycles hypoxanthine to generate substrates for nucleotide synthesis and key metabolites, and here we show that HPRT deficiency in the rat disrupts early embryonic development and causes infertility in females.

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