Intracranial mature teratoma in a pet rabbit

A mature intracranial teratoma was identified in a 5-month-old pet rabbit showing a sudden onset of obtundation, recumbency, flaccid tetraplegia, and hyporeflexia. A space-occupying suprasellar, irregular cystic mass extending from the thalamus to the brainstem was observed at necropsy. Histologically, the tumor was composed of irregular, multilocular cysts lined by a thin wall and interposed tissue where a heterogeneous collection of structures including adipose and myxomatous tissues, cartilage, glandular and ductal structures, skeletal muscle, nervous tissue, nerve fascicles, sebaceous glands, and exocrine pancreatic cells were recognized. Immunohistochemistry showed labeling of the diverse tissues with cytokeratin, vimentin, smooth muscle actin, GFAP, NSE, and S-100.