Data-driven prioritization and preclinical evaluation of therapeutic targets in glioblastoma.

Cyrillo G Brahm,U Kulsoom Abdul,Megan Houweling,Myra E van Linde,Tonny Lagerweij,Henk M W Verheul,Bart A Westerman,Annemiek M E Walenkamp,Rudolf S N Fehrmann

Neuro-oncology advances（2020）

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摘要

The MAPK9 inhibitor RGB-286638 showed promising in vitro results. Furthermore, in vivo target engagement studies and combination therapies with this compound warrant further exploration.

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关键词

MAPK9,RRM2,XIAP,glioblastoma,therapeutic targets

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