Pathophysiology and multidisciplinary management of leg wounds in sickle cell disease: A case discussion and literature review

Patients with sickle cell disease and recalcitrant wounds due to trauma, burns, or chronic venous insufficiency are at risk for compromised healing potential. Diminished oxygen supply as a consequence of anemia and ischemia associated with sickle cell disease result in poor wound closure of the affected area. This article will review the pathophysiology of sickle cell disease, particularly as it relates to associated lower extremity wounds. The case study of a 29-year-old man with sickle cell disease is used to present a successful strategy for treating these types of wounds.