Human Dopaminergic Neurons Lacking PINK1 Exhibit Disrupted Dopamine Metabolism Related to Vitamin B6 Co-Factors

Christine Bus,Laimdota Zizmare,Marita Feldkaemper,Sven Geisler,Maria Zarani,Anna Schaedler,Franziska Klose,Jakob Admard, Craig J. Mageean,Giuseppe Arena,Petra Fallier-Becker,Aslihan Ugun-Klusek,Klaudia K. Maruszczak, Konstantina Kapolou,Benjamin Schmid,Doron Rapaport,Marius Ueffing,Nicolas Casadei,Rejko Krüger,Thomas Gasser

iScience（2020）

引用 16|浏览31

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摘要

PINK1 loss-of-function mutations cause early onset Parkinson disease. PINK1-Parkin mediated mitophagy has been well studied, but the relevance of the endogenous process in the brain is debated.

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关键词

Molecular Biology,Molecular Neuroscience,Stem Cells Research,Omics

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