Canagliflozin alleviates LPS-induced acute lung injury by modulating alveolar macrophage polarization

Fengyu Lin,Chao Song,Yanjun Zeng,Yi Li,Haitao Li,Ben Liu,Minhui Dai,Pinhua Pan

International Immunopharmacology（2020）

引用 25|浏览14

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摘要

•Canagliflozin (CANA) alleviated LPS-induced ALI in mice.•CANA suppresses LPS-induced M1/M2 macrophage ratio in mice.•CANA alleviates inflammatory response and affects macrophage polarization in LPS-stimulated BMDMs.•CANA suppressed M1 macrophages and promoted M2 macrophages invitro.

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关键词

Acute lung injury,Canagliflozin,Macrophage polarization,Sodium-glucose co-transporter 2 inhibitor

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