Skin intrinsic fluorescence scores are a predictor of all-cause mortality risk in type 1 diabetes: The Epidemiology of Diabetes Complications study

•AGE accumulation is particularly harmful for patients with T1D and have been associated with mortality in T1D.•We sought to identify the relationship between collagen-linked AGE, assessed via SIF scores, and all-cause mortality in T1D.•We found a marginal association between skin intrinsic fluorescence score and mortality which persisted after adjustment for multiple daily insulin shots/pump use.•This association was attenuated after adjustment for T1D duration, A1c months, or estimated glomerular filtration rate.•Our work also demonstrates that non-invasive SIF scores provide a novel approach for monitoring the role of AGEs in T1D.