Integrating LINCS Data to Evaluate Cancer Transcriptome Modifying Potential of Small-molecule Compounds for Drug Repositioning.

Combinatorial chemistry & high throughput screening（2020）

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摘要

Our work establishes CTMP to evaluate the antineoplastic property of small-molecule compounds and suggests CTMP-based systematic screen of cancer type-specific CTMTs as a feasible strategy in drug repositioning for precise anticancer purposes.

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关键词

cancer modifying therapeutics,drug sensitivity,gene signatures,library of integrated network-based cellular signatures

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