Learning Useful Representations of DNA Sequences From ChIP-Seq Datasets for Exploring Transcription Factor Binding Specificities

IEEE/ACM Transactions on Computational Biology and Bioinformatics(2022)

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摘要
Deep learning has been successfully applied to surprisingly different domains. Researchers and practitioners are employing trained deep learning models to enrich our knowledge. Transcription factors (TFs)are essential for regulating gene expression in all organisms by binding to specific DNA sequences. Here, we designed a deep learning model named SemanticCS (Semantic ChIP-seq)to predict TF bindin...
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关键词
DNA,Semantics,Feature extraction,Deep learning,Bioinformatics,Genomics,Data models
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