Cobalt Bis(Dicarbollide) Alkylsulfonamides: Potent And Highly Selective Inhibitors Of Tumor Specific Carbonic Anhydrase Ix

CHEMPLUSCHEM(2021)

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摘要
Invited for this month's cover is a collaboration from three institutes from the Czech Academy of Sciences: Institute of Inorganic Chemistry, Institute of Organic Chemistry and Biochemistry, and Institute of Molecular Genetics, and the University of Pardubice. The cover picture shows a family of potent and selective CA IX inhibitors that combines the structural motif of a bulky inorganic cobalt bis(dicarbollide) polyhedral ion with a propylsulfonamido anchor group. Read the full text of the article at 10.1002/cplu.202000574.
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关键词
anti-tumor agents, carbonic anhydrase IX, carboranes, cobalt, enzyme inhibitors
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