Gene-signatures predict biologically relevant dose-response potencies in phenotypic assays

Steffen Renner,Christian Bergsdorf,Rochdi Bouhelal, Magdalena Koziczak-Holbro,Andrea Marco Amati, Valerie Techer-Etienne, Ludivine Flotte,Nicole Reymann,Karen Kapur,Sebastian Hoersch, Edward J. Oakeley,Ansgar Schuffenhauer, Hanspeter Gubler,Eugen Lounkine,Pierre Farmer

biorxiv（2019）

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摘要

Our results show that gene-signature potencies are a novel valid alternative to conventional readouts for compound potency quantification, in particular in scenarios where no other established readouts are available.

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