Cardiac Microvascular Endothelial Cells in Pressure Overload-Induced Heart Disease.

Sander Trenson,Hadewich Hermans, Sander Craps,Peter Pokreisz,Pauline de Zeeuw, Jore Van Wauwe,Hilde Gillijns, Denise Veltman,Fangfei Wei,Ellen Caluwé,Rik Gijsbers, Pieter Baatsen,Jan A Staessen,Bart Ghesquiere,Peter Carmeliet,Filip Rega,Bart Meuris,Bart Meyns,Wouter Oosterlinck, Jürgen Duchenne,Kaatje Goetschalckx,Jens-Uwe Voigt,Marie-Christine Herregods,Paul Herijgers,Aernout Luttun,Stefan Janssens

ACTA CARDIOLOGICA（2021）

引用 17|浏览66

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摘要

Pressure overload induces major transcriptional and metabolic adaptations in cardiac MiVEC resulting in excess interstitial fibrosis and impaired angiogenesis. Molecular rewiring of MiVEC is worse in women, compromises functional status, and identifies novel targets for intervention.

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关键词

constriction,endothelial cells,heart failure,mice,phenotype

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