Simultaneous determination of nine bisphenol migrations in products related to sanitary and safety of drinking water by auto-solid phase extraction and ultra-performance liquid chromatography with photodiode array and fluorescence detector

Bisphenol analogues in drinking water and their migrations from products related to sanitary and safety of drinking water are potential threat to human health. In this study, a robust method for simultaneous determination of bisphenol A and its eight analogues was developed by an auto-solid phase extraction and ultra-performance liquid chromatography coupled with photodiode array and fluorescence detector. The efficiency of sample preparation was largely improved by optimizing the loading rate of solid phase extraction to 100 mL/min without reducing recovery. The nine bisphenol analogues were separated on an Acquity UPLC BEH C 18 column in 13 min with methanol and water as the mobile phase. The limit of quantification for the nine bisphenol analogues ranged from 20 to 40 ng/L. The recoveries of the method for the target compounds ranged from 77.8 to 121.5% at three spiked levels (40, 200 and 400 ng/L) with the relative standard deviation of 0.54–7.22%. The established method was successfully applied to analyze 62 water samples including bottled drinking water, tap water and soak water of products related to sanitary and safety of drinking water. The developed method was fast, robust and suitable for simultaneous determination of multiple bisphenol analogues in batch samples.