Life-long Dietary Pesticide Cocktail Induces Astrogliosis Along with Behavioral Adaptations and Activates p450 Metabolic Pathways

Wendy Klement,Fabiana Oliviero,Giuseppe Gangarossa, Emma Zub,Frederic De Bock,Isabel Forner-Piquer,Marine Blaquiere,Frederic Lasserre,Jean-Marc Pascussi,Tangui Maurice,Etienne Audinat,Sandrine Ellero-Simatos,Laurence Gamet-Payrastre,Laila Mselli-Lakhal,Nicola Marchi

Neuroscience（2020）

引用 8|浏览30

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摘要

•Long-term pesticides exposure promotes a discrete astrogliosis in the hippocampus.•Long-term pesticide exposure is associated with sex-dependent spatial memory and sociability adaptations.•The continuous exposure to pesticides cocktail significantly activates peripheral P450 metabolic and β-oxidation enzymes.

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Cyp,PDGFRβ,qPCR

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