Five-Step Enantioselective Synthesis of Islatravir via Asymmetric Ketone Alkynylation and an Ozonolysis Cascade.

Aaron Whittaker,Niki R Patel,Mark A Huffman,Xiao Wang, Bangwei Ding,Mark McLaughlin,Justin A Newman,Teresa Andreani,Kevin M Maloney,Heather C Johnson

CHEMISTRY-A EUROPEAN JOURNAL（2020）

引用 3|浏览11

暂无评分

摘要

A 5-step enantioselective synthesis of the potent anti-HIV nucleoside islatravir is reported. The highly efficient route was enabled by a novel enantioselective alkynylation of an a,b-unsaturated ketone, a unique ozonolysis-dealkylation cascade in water, and an enzymatic aldol-glycosylation cascade.

查看译文

关键词

asymmetric alkynylation,biocatalysis,ozonolysis,synthesis

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要