SpatiotemporalDynamicsof Intratumoral ImmuneCells Reveal the Immune Landscape in HumanCancer

Gabriela Bindea,1,2,3,11 Bernhard Mlecnik,1,2,3,11 Marie Tosolini,1,2,3 Amos Kirilovsky,1,2,3 Maximilian Waldner,1,2,3,4 Anna C. Obenauf,5 Helen Angell,1,2,3 Tessa Fredriksen,1,2,3 Lucie Lafontaine,1,2,3 Anne Berger,6 Patrick Bruneval,7 Wolf Herman Fridman,2,3,9 Christoph Becker,4 Franck Pagès,1,2,3,8 Michael R. Speicher,5 Zlatko Trajanoski,10 and Jérôme Galon1,2,3,6,* 1INSERM U872, Laboratory of Integrative Cancer Immunology, Paris 75006, France 2Université Paris Descartes, Paris 75006, France 3Cordeliers Research Centre, Université Pierre et Marie Curie Paris 6, Paris 75006, France 4University of Erlangen-Nuremberg, Erlangen 91001, Germany 5Institute of Human Genetics, Medical University of Graz, Graz 8010, Austria 6Department of General and Digestive Surgery, Assistance Publique-Hopitaux de Paris, Paris 75015, France 7Department of Pathology, Georges Pompidou European Hospital, Paris 75015, France 8Department of Immunology, Georges Pompidou European Hospital, Paris 75015, France 9INSERM U872, Team 13, Paris 75006, France 10Biocenter, Section for Bioinformatics, Innsbruck Medical University, Innsbruck 6020, Austria 11These authors contributed equally to this work *Correspondence: jerome.galon@crc.jussieu.fr http://dx.doi.org/10.1016/j.immuni.2013.10.003