High-throughput screening identifies microRNAs that target Nox2 and improve function following acute myocardial infarction

1 following acute myocardial infarction 2 3 Junyu Yang1,2, Milton E. Brown2, Hanshuo Zhang1; Mario Martinez2; Zhihua Zhao1; Srishti 4 Bhutani2, Shenyi Yin1, David Trac2, Jianzhong Jeff Xi1,2,3,4, Michael E. Davis1,2,5,* 5 6 7 Department of Biomedical Engineering, College of Engineering, Peking University, Beijing, 8 China 9 10 Wallace H. Coulter Department of Biomedical Engineering at Emory University and Georgia 11 Institute of Technology, Atlanta, GA, USA 12 13 State Key Laboratory of Natural and Biomimetic Drugs, Department of Biomedical Engineering, 14 College of Engineering, Peking University, China 15 16 State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Molecular 17 Medicine, Peking University, China 18 19 Division of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, 20 GA, USA 21 22 *Corresponding authors: 23 Michael E. Davis, PhD 24 Associate Professor of Biomedical Engineering 25 Wallace H. Coulter Department of Biomedical Engineering at 26 Emory University and Georgia Institute of Technology 27 1760 Haygood Drive, Suite W200 28 Atlanta, GA 30322 29 michael.davis@bme.emory.edu 30 31 32 33 34 Running title: MicroRNAs targeting Nox2 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 Articles in PresS. Am J Physiol Heart Circ Physiol (February 24, 2017). doi:10.1152/ajpheart.00685.2016