A multi-centre study of ACE and the risk of late-onset Alzheimer ’ s disease

Olivia Belbin*,1,2, Kristelle Brown*,1, Hui Shi1, Christopher Medway1, Richard Abrahams3, Peter Passmore4, David Mann5, A. David Smith6, Clive Holmes7, B. McGuiness4, David Craig4, Donald Warden7, Reinhard Heun8, Heike Kölsch9, Seth Love10, Noor Kalsheker1, Julie Williams3, Michael J Owen3, Minerva Carrasquillo2, Steven Younkin2, Kevin Morgan1,~,#, and Patrick G Kehoe10,~ 1Department of Clinical Chemistry, Institute of Genetics, Queen’s Medical Centre, University of Nottingham, UK 2Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA 3Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Cardiff, UK 4Department of Geriatric Medicine, The Queen’s University of Belfast, Belfast, UK 5Greater Manchester Neurosciences Centre, University of Manchester, UK 6Memory Assessment and Research Centre, University of Southampton, Southampton, UK 7OPTIMA, University Department of Pharmacology, Oxford, UK 8Department of Old Age Psychiatry, Queen Elizabeth Psychiatric Hospital, Birmingham, UK 9University of Bonn, Bonn, Germany 10Institute of Clinical Neurosciences, School of Clinical Science, University of Bristol, Frenchay Hospital, UK