Prenatal exposure to perfluoroalkyl substances modulates neonatal serum phospholipids, increasing risk of type 1 diabetes.

Aidan McGlinchey,Tim Sinioja,Santosh Lamichhane,Partho Sen,Johanna Bodin,Heli Siljander,Alex M Dickens,Dawei Geng,Cecilia Carlsson,Daniel Duberg,Jorma Ilonen,Suvi M Virtanen,Hubert Dirven,Hanne Friis Berntsen,Karin Zimmer,Unni C Nygaard,Matej Orešič,Mikael Knip,Tuulia Hyötyläinen

Environment International（2020）

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摘要

•Over last decade, increasing incidence of type 1 diabetes has stabilized in Finland.•Stabilization of disease incidence coincides with tighter regulation of PFAS.•High prenatal PFAS exposure associates with decreased postnatal serum phospholipids.•High prenatal PFAS exposure associates with appearance of islet autoantibodies.•Prenatal PFAS exposure contributes to increased postnatal risk of type 1 diabetes.

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关键词

Bile acids,Lipidomics,Mass spectrometry,PFAS,Type 1 diabetes

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