Efficacy of nanoparticle encapsulation on suppressing oxidation and enhancing antifungal activity of cyclic lipopeptides produced by Bacillus subtilis.

Nan Lin,Chu Wang,Jinglin Ding,Lijing Su,Linlin Xu,Bo Zhang,Yanyan Zhang,Junfeng Fan

Colloids and Surfaces B: Biointerfaces（2020）

引用 12|浏览2

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摘要

•Cyclolipopeptide (CL) easily oxidizes and loses antifungal action after extraction.•Solid lipid nanoparticle (SLN) effectively protects CL from oxidation.•SLN embedding enhances antifungal activity of CL.•Hydrophobic interactions of CL and SLN enhance the crystallinity of CL-loaded SLN.•CL-loaded SLN has strong affinity to and high permeability across fungal membrane.

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关键词

Nanoparticle,Ochratoxin A,Association efficiency,Loading degree,Membrane permeability

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