Prunella vulgaris L. attenuates experimental autoimmune thyroiditis by inducing indoleamine 2,3-dioxygenase 1 expression and regulatory T cell expansion.

Huanbing Qiu, Jingping Zhang,Qingling Guo,Yongsheng Zhang,Xia Zhong

Biomedicine & Pharmacotherapy（2020）

引用 16|浏览7

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摘要

•Prunella vulgaris L. attenuates thyroiditis and goitre in Tg-immunized EAT model.•Prunella vulgaris L. increased proportion of Treg cells in EAT model.•Prunella vulgaris L. elevated serum levels of IL-10 and TGF-βin EAT model.•Prunella vulgaris L. elevated IDO1 expression and activity in EAT model.

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关键词

Autoimmune thyroiditis,Experimental autoimmune thyroiditis,Prunella vulgaris L.,Regulatory T cell (Treg),Indoleamine 2,3-dioxygenase 1 (IDO1)

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