Abstract 109: Understanding Multi-allelic Heterozygous Variant Contributions to Cardiomyopathy Using iPSCs

Cassandra Happe, Kevin Tenerelli,Dekker C Deacon,Vivien Tran,Hermes Taylor-Weiner,Eric D Adler,Neil C Chi,Adam J Engler

Circulation Research（2016）

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摘要

Dilated cardiomyopathy (DCM) is a multivariate disease with poorly understood mechanisms, but recently hundreds of variants in 30+ genes have been suggested to contribute to disease pathology. As e...

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