Higher odds and rising trends in arrhythmia among young cannabis users with comorbid depression

•Of 2011,598 young cannabis users (59.6% male), 190,146 (9.5%) had comorbid depression.•Cannabis users with depression were more likely older, white and female.•Of 190,146 cannabis users with depression, 6.9% experienced arrhythmias (AF most common).•More rapidly rising trends in arrhythmia were seen among depressed cannabis users (4.9% in 2007 to 8.5% in 2014).•Young depressed cannabis users had ~40% higher odds of arrhythmia compared to non-depressed.