5α-dihydrotestosterone abrogates sex bias in asthma like features in the mouse

Ida Cerqua,Michela Terlizzi,Rossella Bilancia,Maria A. Riemma,Valentina Citi,Alma Martelli,Simona Pace,Giuseppe Spaziano,Bruno D’Agostino,Oliver Werz,Armando Ialenti,Rosalinda Sorrentino,Giuseppe Cirino,Antonietta Rossi,Fiorentina Roviezzo

Pharmacological Research（2020）

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摘要

•5α-dihydrotestosterone is involved in sex bias in asthma disease.•5α-dihydrotestosterone inhibits allergen-induced bronchial hyperreactivity in females.•5α-dihydrotestosterone inhibits mast cell activation/degranulation induced by allergen.

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关键词

DHT,5-LOX,β‐HEX,ELISA,FBS,Hematoxylin and eosinIL,LT,MEM,OVA,PAS

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