Emotional dysregulation and callous unemotional traits as possible predictors of short-term response to methylphenidate monotherapy in drug-naïve youth with ADHD.

•Negative predictors of MPH treatment in youth with ADHD are poorly explored.•Emotional dysregulation might be a negative predictor of MPH short-term response.•Callous unemotional traits were not related to poorer response to MPH.•Emotional dysregulation should be systematically assessed in youth with ADHD.