PABPC5/HCG15/ZNF331 feedback loop regulate vasculogenic mimicry of glioma via STAU1-mediated mRNA decay

Glioma is the most common primary malignancy in the brain, and vasculogenic mimicry (VM) is one of the blood supply methods. Here we investigated the possibility that lncRNAs regulate the stability of transcription factors through the SMD pathway, which affects proliferation, migration, invasion, and the ability to form VMs in glioma. Expression of , , and was detected by real-time qPCR or western blot in glioma. Cell Counting Kit-8, Transwell assays, and VM tube formation were used to investigate , , and function in cell proliferation, migration, invasion, and VM, respectively. ChIP assays were used to ascertain the interaction between and or . and were highly expressed in glioma cells. was lowly expressed. bound to increase its stability. Knockdown reduced the degradation of ZNF331 mRNA by the SMD pathway. inhibited transcription through binding to the promoter region of and and inhibited the ability to form VMs in glioma cells. The feedback loop plays an important role in regulating VM formation in glioma and provides new targets for glioma treatment.