THE COMPARISON OF VENOUS SEQUENTIAL AND NORMAL GRAFT PATENCY BASED ON HEMODYNAMICS

Background: In coronary artery bypass grafting (CABG), the patency of venous sequential graft remains controversial. Hemodynamic factors have been proved to be the important factors influencing graft patency. The objective of this study is to compare the patency of sequential grafts and normal grafts by hemodynamic environment. Methods: This study used a patient's clinical data to construct a 0D/3D coupled multi-scale model, and used this model to calculate graft's hemodynamics under two grafting methods. Meanwhile, CABG ideal models were constructed based on grafts' flow data of 60 patients (63 normal grafts, 19 sequential grafts) to calculate grafts' hemodynamics. Results: Based on the multi-scale model, it was found that the sequential graft flow and time average wall shear stress (TAWSS) were higher than normal graft, which was good for graft patency. But there were a flow separation region, some regions of high oscillatory shear index (OSI) and relative residence time (RRT) in sequential graft, which could lead to intimal hyperplasia. Based on ideal CABG models, it was known that failure rate of sequential and normal grafts were 36.8% and 36.5%, and there were significant differences between them in flow rate, TAWSS and OSI (sequential versus normal: flow rate (ml/min): 42.26 +/- 17.98 versus 27.33 +/- 14.52, TAWSS (Pa): 0.71 +/- 0.28 versus 0.54 +/- 0.25, OSI: 0.0114 +/- 0.0029 versus 0.0047 +/- 0.0020). Conclusion: For saphenous venous graft (SVG), although the normal graft has similar patency with the sequential graft, the hemodynamic mechanism behind it is different. In flow rate and WSS, sequential grafts have an advantage over normal grafts. But there are high OSI and RRT regions in sequential grafts.