Disodium cromoglycate treatment reduces T H 2 immune response and immunohistopathological features in a murine model of Eosinophilic Esophagitis.

Flávia Márcia de Castro E Silva,Erick Esteves de Oliveira,Marcilene Gomes Evangelista Ambrósio,Marina Caçador Ayupe,Viviane Passos de Souza,Laura Machado Menegati,Daniele Ribeiro de Lima Reis,Marco Antonio Machado,Gilson Costa Macedo,Ana Paula Ferreira

International Immunopharmacology（2020）

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摘要

•Disodium cromoglycate reduced remodeling in esophagus in EoE experimental model.•The treatment reduces eosinophilic influx and IL-5 mRNA expression.•Mast cell number and activation were reduced by the treatment.•Th2 immune response in peripheral lymphoid organs was also reduced.

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关键词

Allergy,Eosinophilic esophagitis,Immune response,Inflammation,Disodium cromoglycate

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