c-Jun NH2-terminal kinase (JNK)/stress-activated protein kinase-associated protein 1 is a critical regulator for arthritis progression by meditating inflammation in mice model.

•JIP3 knockout attenuates the pathogenesis and inflammatory response in joints of CIA mice.•JIP3 deletion alleviates inflammation in joints of CIA mice via suppression of TLRs/NF-κB and JNK signaling pathways.•JIP3 activates JNK to enhance inflammation in RANKL-treated RAW264.7 cell.