Spatiotemporal EEG microstate analysis in drug-free patients with Parkinson's disease.

•We have found that PD can be characterized by unique spatial microstate different from healthy controls, which may be related to the brain dysfunction in PD.•The drug-free patients with PD show abnormal brain dynamics revealed by the regular changes of temporal microstate features in early PD and such temporal dynamics in microstates are correlated with motor function and cognition of the subjects.•The obtained results may deepen our understanding of the brain dysfunction caused by PD, and obtain some quantifiable signatures to provide an auxiliary reference for the early diagnosis of PD.