Eicosapentaenoic acid prevents salt sensitivity in diabetic rats and decreases oxidative stress

•Salt Sensitivity prevention in Diabetes Mellitus.•Hypertension is an important risk factor for cardiovascular disease and mortality, characterized by a slow inflammation process.•Activation of Nrf-2 via eicosapentaenoic acid supplementation may be a strategy in diabetes mellitus to prevent renal oxidative stress generation and finally the development of Hypertension.