Construction of a new In(III)-based coordination polymer for selective luminescent detection of Cr2O72− and anti-bacterial protective effect on Staphylococcus aureus infection after missed abortion

A new luminescent In(III)-based coordination polymer with the chemical formula of {[In(ipa)(H2O)](H2O)(CH3CN)(2)}(n) (1, H(3)ipa = 5-hydroxyisophthalate) has been successfully prepared via a solvothermal reaction of H(3)ipa and In(NO3)(3)center dot 6H(2)O in CH3CN and DMF mixed solvent. The strong emission of 1 could be quenched efficiently by trace amounts of Cr2O72-, while other competing analogues show no such quenching effect, indicating complex 1 could be applied as an effective sensor for the detection of Cr2O72- in the solution. To solve the problem of bacterial infection after missed abortion, the protective effect of the compound in vivo was further explored. CFU detection was carried to evaluate the inhibitory effect of compound on bacterial numbers, and then ELISA was conducted to detect the level of IL-18 and IL-1 beta in the infectious tissues. The pharmacokinetic detection of the compound was also performed in SD rats. The results obtained from molecular docking and pose scoring software exhibited a possible binding mode of the compound binding to NF kappa B, which might provide potential regulation mechanisms for the compound.