Development of 1,3-thiazole analogues of imidazopyridines as potent positive allosteric modulators of GABA A receptors.

Tatyana A Tikhonova,Irina V Rassokhina,Eugeny A Kondrakhin, Mikhail A Fedosov,Julia V Bukanova,Alexey V Rossokhin,Irina N Sharonova, Georgy I Kovalev,Igor V Zavarzin,Yulia A Volkova

Bioorganic Chemistry（2020）

引用 13|浏览14

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摘要

Structural basis for activity of benzo[d]imidazo[2,1-b]thiazoles were proposed using extensive molecular docking studies.

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关键词

Positive allosteric modulators,GABAA receptors,Imidazopyridine drugs,Imidazo[2,1-b]thiazoles,Imidazo[2,1-b][1,3,4]thiadiazoles,Benzo[d]imidazo[2,1-b]thiazoles,Benzodiazepine-binding site

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