Synthesis and the First Structure–Activity Relationship Study of Imidazole Alkaloid from Red Ascidian as Aldose Reductase Inhibitors

Ryota Saito, Kenta Morikawa,Sota Uno,Shoko Higashi,Masaru Goto

Heterocycles（2019）

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摘要

We synthesized a series of 2-aroyl-4-aryl-1H-imidazoles (2 and 3) and evaluated their in vitro AR inhibitory activity for the first time. We observed improved activities with derivatives having multiple catechol moieties.

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