Bisperoxovanadium induces M2-type macrophages and promotes functional recovery after spinal cord injury.

Jia Liu,Kai Li,Jing Zhou,Tian Sun,Chengliang Yang,Jihua Wei,Kegong Xie,Qisheng Luo,Yujin Tang

Molecular Immunology（2019）

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摘要

•Inhibition of PTEN activity promotes macrophage polarization to an M2 phenotype.•Targeting PTEN enhances the macrophages towards to M2 polarization and promotes the functional recovery in SCI.•PTEN may be a future therapeutic target for SCI treatment.

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关键词

Bisperoxovanadium,M2-type macrophages,Acellular spinal cord,Spinal cord injury,PTEN

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