Development of a highly efficient decontamination approach for ceftolozane in the pharmaceutical manufacturing environment.

Rong-Sheng Yang,Li-Kang Zhang,Roy Helmy,Teresa Andreani,Zhijian Liu,Huaming Sheng

Journal of Pharmaceutical and Biomedical Analysis（2020）

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摘要

•A highly efficient decontamination method was developed for ceftolozane as well as other cephalosporin antibiotics.•UHPLC-HRMS/MS method is sensitive and efficient for the detection, identification and characterization of beta-lactam-ring destruction.•The presence of an intact beta-lactam-ring structure was characterized by the detection of CO loss in LC/HRMS/MS.

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关键词

Cedftolozane,β-lactam antibiotics,β-lactam ring opening,UHPLC-HRMS/MS

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