Cell Motion Alignment As A Polarity Memory Effect

Clarification of the motion alignment mechanism in collective cell migration is a common issue for physics and biology. Analogous to the self-propelled disk, the polarity memory effect of a eukaryotic cell is a fundamental candidate for this alignment mechanism. In this study, we theoretically examined the polarity memory effect for the motion alignment of cells on the basis of the cellular Potts model. We illustrated that the polarity memory effect can align the motion of cells. We also observed that the polarity memory effect occurs when the persistent length of cell trajectories is longer than the average cell-cell distance.