Macrophage NLRP3 inflammasome activated by CVB3 capsid proteins contributes to the development of viral myocarditis.

Jingyin Bao,Tianle Sun,Yan Yue,Sidong Xiong

Molecular Immunology（2019）

引用 24|浏览9

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摘要

•NLRLP3 inflammasome was activated in the cardiac macrophages of CVB3-infected mice.•NLRP3 activacted macrophages contributed greatly to the pathogenesis of myocarditis.•CVB3 capsid proteins VP1 and VP2 triggered macrophage NLRP3 inflammasome activation.

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关键词

NLRP3,CVB3,Capsid protein,Macrophages,Viral myocarditis

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