Mixed-Fleet Single-Terminal Bus Scheduling Problem: Modelling, Solution Scheme and Potential Applications

•We extend our previous mixed-fleet scheduling model with optimized memory requirements, addressing real-size instances.•We introduce an ad-hoc decomposition scheme to solve problems with an arbitrary number of trips, fleet size and composition.•We validate the proposed MILP and solution methods through two test cases arising in the city of Luxembourg.•We perform sensitivity analysis of the model's solutions to degree of decomposition, fleet size and fleet composition.•We numerically assess the proposed MILP and solution method's scalability capabilities.