Dopamine-Mediated Immunomodulation affects Choroid Plexus Function.

Giulia Castellani,Gabriella Contarini,Maddalena Mereu, Ennio Albanesi,Céline Devroye,Claudio D'Amore,Valentina Ferretti,Sara De Martin,Francesco Papaleo

Brain, Behavior, and Immunity（2019）

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摘要

•DAT genetic hypofunction results in a general immunotolerance.•Amphetamine exposure produce a general immunotolerance.•DAT-by-amphetamine interaction aberrantly modulates the choroid plexus gateway.

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关键词

DAT,Amphetamine,Peripheral and CNS immune crosstalk,ADHD,Microglia,Macrophages

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