Film-nanoparticle composite for enhanced oral delivery of alpha-casozepine.

•Alpha-casozepine peptide was successfully entrapped within PLGA nanoparticles.•Nanoparticles were incorporated in guar-gum films for improved peptide buccal permeability.•Nanoparticles were incorporated in guar-gum films for improved peptide intestinal permeability.•Film-nanoparticle association represent an innovative delivery system for peptides.