Cell based therapy reduces secondary damage and increases extent of microglial activation following cortical injury.

Mary E Orczykowski,Samantha M Calderazzo,Eli Shobin,Monica A Pessina,Adrian L Oblak,Seth P Finklestein,Brian C Kramer,Farzad Mortazavi,Douglas L Rosene,Tara L Moore

Brain Research（2019）

引用 8|浏览24

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摘要

•Oxidative damage is lower in the sublesional white matter with hUTC treatment.•Perilesional iron accumulation is lower with hUTC treatment.•Extent of microglial activation is higher in the white matter with hUTC treatment.•Lesion volume and oxidative damage are associated with iron accumulation.

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关键词

Cell based therapy,hUTC: human umbilical tissue-derived cells,Cortical damage,Secondary damage,Oxidative stress,Microglia

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