Thermo-Chemo-Radiotherapy Association

This chapter focuses on the biological rationale and the advantages for combining hyperthermia radiotherapy and chemotherapy. Other clinical aspects such as sequence of administration, effects on drug uptake and methods used to improve the efficacy of HT are also discussed. The actual applications and effects of HT on brain are presented. Furthermore, the preliminary clinical results obtained, by our group, on malignant brain tumors using this triple combination of cure are illustrated. The survival curves of brain tumors in total and of glioblastomas, treated with HT, were compared to the single standard application of conformational radiotherapy. The life quality and survival results are favorable to HT, however the number of patients treated is limited. In every case we suggest its use for better clinical control of the disease.