A new animal model of insulin-glucose dynamics in the intraperitoneal space enhances closed-loop control performance

•State-of-the-art control algorithms delivering insulin subcutaneously (SC) to treat type 1 diabetes (T1D) exhibit slow diffusion and lag.•Alternative insulin delivery sites such as the intraperitoneal cavity have demonstrated benefits in prior simulation studies.•A transfer function model of insulin-glucose dynamics in the IP space is constructed from canine data.•The new transfer function is used to design a PID controller with insulin feedback to prevent controller-induced hypoglycemia.•Experiments support knowledge that insulin clearance rate in the IP space faster than in SC; shows potential in next-gen artificial pancreas.