Dantrolene Enhances Binding Of Calmodulin To Ryr2 In Cpvt Which Mutation Located At Central Domain But Does Not Enhance That In Cpvt With Mutation At Cam-Like Domain

Shigehiko Nishimura,Takeshi Yamamoto, Go Fukui,Takako Maeda,Akihiro Hino,Takeshi Suetomi,Makoto Ono,Mamoru Mochizuki,Tetsuro Oda,Shinichi Okuda,Shigeki Kobayashi,Masafumi Yano

CIRCULATION（2015）

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摘要

Introduction: Catecholaminergic polymorphic ventricular tachycardia (CPVT) is caused by heterozygous mutation in RyR2 gene. Most mutations are known to be located at N-terminal domain, central doma...

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关键词

Ventricular arrhythmia,Calcium,Excitation-contraction coupling (ECC),Sarcoplasmic reticulum

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